Table 3.

Correlation of clinical and molecular factors and response to adjuvant therapy in pediatric low-grade gliomas

Variable	P value, radiotherapy in regimen (N = 17)	P value, chemotherapy in regimen (N = 11)
Age <5 years	0.75	0.50
DMBS location	0.24	0.17
Non-PA morphology	0.64	0.62
High p53	0.53	0.31
P16 deleted	0.97	0.33
MIB1 >10%	0.081	0.50
BRAF rearranged	0.99	1.0
BRAF V600E	0.68	0.18

After initial surgery, 40 cases of pediatric low-grade gliomas were exposed to adjuvant chemotherapy and/or radiation, with clinical response judged as either poor, partial with regrowth, or good (see Methods Results, and Supplementary Table S2). By multiple regression, a high MIB1 proliferation index showed a trend toward correlating with worse response to radiotherapy but no correlation with regimens containing chemotherapy. No other variable showed any relation to adjuvant therapeutic responses. Modeling with fewer variables (eg, excluding V600E, p53, and p16) to include more cases showed no major differences in P values (not shown).