Table 1.
Patient clinical features and treatment characteristics in the whole group and in the 2 subgroups according to postoperative treatment
| Characteristics | Total | RT Alone | RT + CHT | Chi-square P |
|---|---|---|---|---|
| n (%) | n (%) | n (%) | ||
| 295 (100) | 97 (32.9) | 198 (67.1) | ||
| Age | ||||
| ≤50 years | 123 (41.7) | 36 (37.1) | 87 (43.9) | 0.52 |
| 51–60 years | 63 (21.4) | 23 (23.7) | 40 (20.2) | |
| >60 years | 109 (36.9) | 38 (39.2) | 71 (35.9) | |
| Gender | ||||
| Male | 192 (65.1) | 65 (67.0) | 127 (64.1) | 0.62 |
| Female | 103 (34.9) | 32 (33.0) | 71 (35.9) | |
| Number of lesions | ||||
| Single | 280 (94.9) | 92 (94.8) | 188 (94.9) | 0.97 |
| Multiple | 15 (5.1) | 5 (5.2) | 10 (5.1) | |
| Presenting symptoms | ||||
| Focal symptoms | 194 (65.7) | 63 (64.9) | 131 (66.2) | 0.84 |
| Cranial hypertension | 76 (25.8) | 39 (40.2) | 46 (23.2) | 0.15 |
| Seizure | 98 (33.2) | 28 (28.9) | 70 (35.4) | 0.27 |
| None | 2 (0.7) | – | – | – |
| Preoperative KPS | ||||
| 90–100 | 110 (37.3) | 23 (23.7) | 47 (23.7) | 0.14 |
| 80 | 116 (39.3) | 41 (42.3) | 75 (37.9) | |
| ≤70 | 69 (23.4) | 33 (34.0) | 36 (18.2) | |
| Postoperative KPS | ||||
| 90–100 | 161 (54.6) | 41 (42.3) | 120 (60.6) | 0.002 |
| 80 | 60 (20.3) | 20 (20.6) | 40 (20.2) | |
| <70 | 74 (25.1) | 36 (37.1) | 38 (19.2) | |
| RPA class | ||||
| I | 93 (31.6) | 27 (27.8) | 66 (33.3) | 0.19 |
| II | 24 (8.1) | 6 (6.2) | 18 (9.1) | |
| III | 42 (14.2) | 15 (15.5) | 27 (13.6) | |
| IV | 82 (27.8) | 24 (24.7) | 58 (29.3) | |
| V | 54 (18.3) | 25 (25.8) | 29 (14.6) | |
| VI | – | – | – | |
| RPA classes 1–3 vs 4–5 | ||||
| I–III | 159 (53.9) | 48 (49.5) | 111 (56.1) | 0.29 |
| IV–V | 136 (46.1) | 49 (50.5) | 87 (43.9) | |
| RPA classes 1–2 vs 3 vs 4–5 | ||||
| I–II | 117 (39.7) | 33 (23.7) | 84 (42.4) | 0.38 |
| III | 42 (14.2) | 15 (76.3) | 27 (13.6) | |
| IV–V | 136 (46.1) | 49 (50.5) | 87 (43.9) | |
| Surgical procedure | ||||
| Biopsy | 70 (23.7) | 23 (23.7) | 47 (23.7) | 1.00 |
| Exeresis | 225 (76.3) | 74 (76.3) | 151 (76.3) | |
| 3D-CRT | ||||
| Yes | 254 (86.1) | 73 (75.3) | 181 (91.4) | 0.002 |
| No | 41 (13.9) | 24 (24.7) | 17 (8.6) | |
| RT fraction size | ||||
| 1.8 Gy | 19 (6.4) | 4 (4.1) | 15 (7.6) | 0.0007 |
| 2 Gy | 248 (84.1) | 75 (77.3) | 173 (87.4) | |
| 3 Gy | 28 (9.5) | 18 (18.6) | 10 (5.1) | |
| RT total dose for 1.8/2 Gy per fraction | ||||
| <60 Gy | 33 (11.2) | 17 (17.5) | 16 (8.1) | 0.005 |
| 60 Gy | 178 (60.3) | 43 (44.3) | 135 (68.2) | |
| >60 Gy | 56 (19.0) | 19 (19.6) | 37 (18.7) | |
| RT total dose for 3 Gy per fraction | ||||
| ≤39 Gy | 14 (4.7) | 9 (9.3) | 5 (2.5) | 0.05 |
| >39 Gy | 14 (4.7) | 9 (9.3) | 5 (2.5) | |
| Delay of RT | ||||
| ≤45 days | 114 (38.7) | 31 (32.0) | 83 (41.9) | 0.13 |
| >45 days | 124 (42.0) | 45 (46.4) | 79 (39.9) | |
| Unknown | 57 (19.3) | – | – | |