Fig. 3.

miR-181d expression level inversely correlates with MGMT mRNA level. (A) Correlation between miR-181d and MGMT transcript level in 223 TCGA patients with characterized MGMT promoter, MGMT mRNA level, and miR181-d level (P = .09, R² = 0.09). (B) Correlation of miR-181d and MGMT transcript level in 159 patients with unmethylated MGMT promoter (P = .004, R² = 0.13). Relative abundance of MGMT and miR-181d is plotted on the x- and y-axes. (C) Inverse correlation between miR-181d and MGMT transcript level in an independent set of 11 glioblastomas (P = .04, R² = 0.62). Expression levels of miR-181d and MGMT were assessed by qRT-PCR. Relative abundance of each is plotted on the x- and y-axes.