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. Author manuscript; available in PMC: 2013 Mar 1.
Published in final edited form as: Pain. 2012 Jan 31;153(3):710–721. doi: 10.1016/j.pain.2011.12.013

Figure 1.

Figure 1

Attenuation of at-level mechanical allodynia by inhibition of pCaMKII activation following contusive SCI. The percentage of supraspinal nociceptive responses (y axis) made by naïve (Naïve), sham (Sham) and spinal injured rats (SCI) tested weekly for 35 days post injury is graphed. The SCI rats showed a significant increase in supraspinal responses to both von Frey stimulation (A, p < 0.0001) and stimulation with a 4 mm blunt probe (B, p < 0.0001). Prior to KN-93 injection, SCI rats displayed at-level mechanical allodynia (as evidenced by an increased percentage of supraspinal nociceptive responses). Administration of KN-93 dose dependently reversed this at-level mechanical allodynia to both von Frey stimulation (C) and stimulation with a 4 mm blunt probe (D). Administration of KN-93 had no effect on sham rats. *: significant differences between before and after KN-93 treatment.