Skip to main content
. Author manuscript; available in PMC: 2013 Mar 1.
Published in final edited form as: Pain. 2012 Jan 31;153(3):710–721. doi: 10.1016/j.pain.2011.12.013

Figure 8.

Figure 8

CaMKII inhibition significantly decreases neuronal responses to graded von Frey stimulation at the near level of contusive SCI. (A-D) show spike frequency histograms of neuronal activity to graded von Frey stimuli before (A) and 15 mins (B), 45 mins (C) and 75 mins (D) after KN-93 administration. (E) Mean activity (±SEM) to 0.6 gm, 2 gm, 6 gm, 26 gm, and 60 gm von Frey stimuli applied to the skin rostral to the site of SCI 15 minutes after drug administration. KN-93 significantly attenuated neuronal activity to 0.6 gm, 2 gm, 6 gm, 26 gm and 60 gm von Frey stimuli (p < 0.001) whereas KN-92 had no effect.