Table 2. Memory B cell (MBC) expressed as the mean number of malaria antigen specific SFC cells to apical membrane antigen (AMA1) or merozoite surface protein 1 (MSP1) compared to total IgG SFC (i.e., ASC ratio) measured in children with (SP) or without (SN) S. haematobium infection and stratified by age group and season (i.e., malaria transmission and dry season).

Malaria Antigen	Age (years)	Groupa	MBC Transmission	MBC Dry	P valueb
AMA1	4–14	SP + SN	0.071	0.056	0.16
		SP	0.085	0.061	0.08
		SN	0.048	0.046	0.94
	4–8	SP + SN	0.063	0.036	0.05
		SP	0.070	0.045	0.11
		SN	0.049	0.020	0.28
	9–14	SP + SN	0.079	0.074	0.77
		SP	0.096 c	0.074	0.35
		SN	0.050	0.073	0.41
MSP1	4–14	SP + SN	0.026	0.024	0.69
		SP	0.031	0.019	0.04
		SN	0.017	0.033	0.15
	4–8	SP + SN	0.019	0.009	0.07
		SP	0.022	0.008	0.049
		SN	0.013	0.011	0.86
	9–14	SP + SN	0.032	0.038	0.53
		SP	0.038	0.029	0.12
		SN	0.023	0.054	0.12

^aA total of 53 SP (26 aged 4–8 years, 27 aged 9–14 years) and 29 SN (14 aged 4–8 years, 15 aged 9–14 years) were examined in both the transmission and dry season (Note: Sample for 1 SP and 1 SN were excluded from the wet and from the dry season for a total of 4 samples).

^bStatistical analysis performed between transmission and dry season values using paired ttest (two-tailed). P value deemed statistically significant ≤0.05.

^cStatistical significance measured between SP and SN values using the Mann Whitney test for values not normally distributed (P value ≤0.05).

ASC ratios ≥0.01 were defined as a positive specific MBC responses. Mean age-stratified group values ≥0.01 are depicted in bold font.