Table 4. Geometric mean antibody titers (OD 450 nm) stratified by antigen, season and schistosoma status in children with (SP) and without (SN) S. haematobium.
| Cohort | Season | Antigen | Ab Titer c | SP vs. SNP Valuea | Ab vs. MBC (ρ)c | 95% CIb | P value | Ab vs. Age (ρ)c | 95% CIb | P value |
| SP | Wet | AMA1 | 49,667 | 0.34 | 0.6567 | 0.5034–0.7699 | <0.0001 | 0.1497 | −0.0805–0.3648 | 0.19 |
| SN | 37,345 | |||||||||
| SP | Dry | 57,534 | 0.10 | 0.5229 | 0.3281–0.6750 | <0.0001 | 0.1767 | −0.0576–0.3926 | 0.13 | |
| SN | 24,720 | |||||||||
| Negatived | 86 | |||||||||
| Positived | 108,579 | |||||||||
| SP | Wet | MSP1 | 34,172 | 0.56 | 0.4131 | 0.2034–0.5866 | 0.0002 | 0.2639 | 0.0398–0.4636 | 0.02 |
| SN | 50,081 | |||||||||
| SP | Dry | 25,956 | 0.51 | 0.4046 | 0.1920–0.5808 | 0.0003 | 0.3077 | 0.0847–0.5013 | 0.006 | |
| SN | 20,568 | |||||||||
| Negative | 121 | |||||||||
| Positive | 58,292 | |||||||||
| SP | Wet | SEA | 25,539 | <0.0001 | 0.5785 | 0.4016–0.7138 | <0.0001 | 0.2910 | 0.0083–0.5306 | 0.03 |
| SN | 2,270 | |||||||||
| SP | Dry | 37,309 | <0.0001 | 0.5355 | 0.3343–0.6751 | <0.0001 | 0.1576 | −0.1317–0.4221 | 0.27 | |
| SN | 2,859 | |||||||||
| Negative | 473 | |||||||||
| Positive | 8,521 | |||||||||
| SP | Wet | SWAP | 4,511 | <0.0001 | 0.3108 | 0.0866–0.5051 | 0.006 | 0.1690 | −0.1201–0.4317 | 0.24 |
| SN | 818 | |||||||||
| SP | Dry | 7,238 | <0.0001 | 0.2616 | 0.0316–0.4653 | 0.02 | 0.2856 | 0.0025–0.5264 | 0.04 | |
| SN | 858 | |||||||||
| Negative | 126 | |||||||||
| Positive | 3,612 |
Statistical analysis performed between children with and without S. haematobium using the Mann Whitney test. P value deemed statistically significant ≤0.05. Statistical analysis between transmission and dry season values is not shown but no statistical significance was noted.
95% Confidence Interval of Spearman rank correlation test.
Ab refers to geometric mean antibody and age refers to age-in-months. Spearman rank correlation (ρ) is depicted.
Geometric mean antibody titers are reported for negative controls (10 U.S. malaria naïve adult sera) and positive controls (10 pooled Malian adult sera).
Also depicted are geometric mean negative and positive control values for each antigen. Spearman rank correlation (ρ) testing and 95% confidence interval depicting strength of association between antibody tested and MBC results as well as antibody tested and the child’s age in months.