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. 2012 Jun 5;7(6):e38787. doi: 10.1371/journal.pone.0038787

Figure 4. Effect of G1 on the relaxation response to ACh or SNP.

Figure 4

(A) Capability of the relaxation induced by ACh (10−9 M to 10−5 M) was reduced in diabetic OVX rats as compared with OVX rats. Long-term administration of G1 (200 ug/kg i.p., 2/per day, 8 weeks) increased the capability of vasorelaxation as shown by the Emax and pD2. (B) The capability of the relaxation caused by SNP (10−9 M to 10−5 M) had no difference in the aortic segments among the three groups. n = 6–12 rings from 5–8 rats. ** p<0.01 compared with OVX rats; # p<0.05 compared with diabetic OVX rats. Results are given as the mean ± SEM of three independent experiments.