Fig. 2.

Pathobiological implication of CCN5/WISP-2. CCN5/WISP-2 is differentially expressed in different cellular environments of normal breast and breast cancer samples. CCN5/WISP-2 expression in undetected or minimally detected in normal breast epithelial and its expression is predominantly in the nucleus. CCN5/WISP-2 over expressed in non-invasive breast cancer cells and its expression gradually disappears as the disease progressed from non-invasive to invasive cancers with or without ER-α positivity. Highly aggressive cells show no expression of CCN5/WISP-2