Fig. 7.
Shrinkage of the distribution of Up and Down durations by increasing the slice excitability. a Average Up state duration versus the duration change when a GABAA antagonist (making less effective the inhibitory synaptic transmission) was injected (n = 31, 0.2 μM of BMI; n = 11, 0.2 μM of SR). Red dashed curve, quadratic polynomial fit: y = −0.71 x2 + 0.37 x−0.053. Red circle is the maximum of the parabola, occurring at 260 ms of average Up state duration. b Same as Panel A for average Down state durations, plotted versus their duration changes when drug is injected. Red circle is where the quadratic fit (red dashedline) y = −0.007 x2−0.46 x + 1.1, has a vanishing duration change, which occurs at Down duration of 2.4 s