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. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: Comp Immunol Microbiol Infect Dis. 2012 Mar 14;35(4):309–317. doi: 10.1016/j.cimid.2012.01.012

Figure 4. Increased production of TNF-α and IL-6 from lung cDCs and macrophages in the absence of pDCs.

Figure 4

(A) Peak TNF-α(left) and IL-6 (right) production detected by intracellular cytokine analysis from pDCs before and during early (day 1-3) or late (day 4-6) acute influenza virus infection in pDC-intact mice. (B) Representative dot plots of TNF-αand IL-6 production from MHC class II+ CD11c+ cells post-infection. (C) Intracellular TNF-α(left) and IL-6 (right) production from cDCs (top), exudate macrophages (middle) and alveolar macrophages (bottom) from pDC-intact (black bars) and pDC-depleted mice (grey bars) before infection and during early (day 1-3) or late (day 4-6) infection. Shown are means ± SEM. * P<.05 between groups.