Table 2.
Cytokine receptor SNPs associated with measles-specific humoral (Ab) and cell-mediated (CMI) immune response extremes following 2 doses of MMR vaccination.
| Gene | SNP (variant name) | Genotype | AblowCMIlow (N=30) | AblowCMIhigh (N=30) | AbhighCMIlow (N=30) | AbhighCMIhigh (N=30) | χ2 Pa for all Quadrants | χ2 Pa for AblowCMIlow vs. AbhighCMIhigh |
|---|---|---|---|---|---|---|---|---|
| IL4RA | rs1805010 (Ex5+14C) | AA | 6 (20) | 11 (37) | 7 (23) | 6 (20) | 0.21 | 0.09 |
| GA | 15 (50) | 11 (37) | 17 (57) | 20 (67) | ||||
| GG | 9 (30) | 8 (27) | 6 (20) | 4 (13) | ||||
| IL12RB1 | rs372889 (IVS14-517C) | AA | 10 (33) | 9 (30) | 8 (27) | 4 (13) | 0.12 | 0.03b |
| GA | 15 (50) | 11 (37) | 17 (57) | 13 (43) | ||||
| GG | 5 (17) | 10 (33) | 5 (17) | 13 (43) | ||||
| IL12RB2 | rs3790567 (IVS8+5606A) | AA | 4 (13) | 2 (7) | 2 (7) | 0 (0) | 0.32 | 0.38 |
| GA | 12 (40) | 14 (47) | 6 (20) | 11 (37) | ||||
| GG | 14 (47) | 14 (47) | 22 (73) | 19 (63) | ||||
a
P-values based on multi-categorical logistic regression analysis, adjusted for age at enrollment, gender, race, age at first MMR and age at second MMR
b
Statistically significant association (P≤0.05)