Table 1.
Basic characteristics of two studied cohorts
| Hong Kong Southern Chinese extreme cohorta | Hong Kong Osteoporosis Study prospective cohortb | ||||||
|---|---|---|---|---|---|---|---|
| High BMD group | Low BMD group | P value | BMD group | Vertebral fracture | |||
| No fracture group | With fracture group | P value | |||||
| Subjects number | 663 | 909 | 2,509 | 1,469 | 277 | ||
| Age (years) | 47.7 (15.46) | 50.5 (16.02) | <0.05 | 63.6 (8.81) | 62.4 (8.31) | 68.0 (9.10) | <0.01 |
| Height (m) | 1.61 (0.08) | 1.55 (0.08) | <0.01 | 1.56 (0.08) | 1.57 (0.08) | 1.54 (0.08) | <0.01 |
| Weight (kg) | 63.59 (10.91) | 50.73 (8.66) | <0.01 | 57.65 (10.12) | 58.04 (10.02) | 56.80 (10.77) | 0.06 |
| BMD (g/cm2) | |||||||
| Lumbar spine | 1.09 (0.13) | 0.74 (0.13) | <0.01 | 0.85 (0.18) | 0.87 (0.18) | 0.80 (0.18) | <0.01 |
| Femoral neck | 0.86 (0.12) | 0.58 (0.09) | <0.01 | 0.65 (0.12) | 0.67 (0.12) | 0.60 (0.13) | <0.01 |
| BMD z-score | |||||||
| Lumbar spine | 1.16 (0.84) | −1.43 (0.68) | <0.01 | −0.24 (1.13) | −0.17 (1.34) | −0.40 (1.25) | <0.05 |
| Femoral neck | 1.10 (0.82) | −1.25 (0.66) | <0.01 | −0.20 (0.98) | −0.11 (0.99) | −0.36 (1.03) | <0.01 |
Data are expressed as mean (SD). The t test was conducted for phenotype comparison between high and low BMD groups for extreme cohort and between groups with and without vertebral fracture for prospective cohort
aThe basic characteristics of the lumbar spine and femoral neck sub-groups of the extreme cohort are detailed in Table S1 (ESM 1)
bA total of 2,509 subjects with BMD data were included in the prospective cohort, and 1,746 of them had the data of vertebral fracture