Table 2.
Association results of eight polymorphic SNPs with BMD variation in the tSNP-based association study (HKSC extreme cohort, n = 1,572)
| SNP | Genomic position | Genic position | Alleles major/minor | MAF | HWE (P) | Either LS or FN | LS | FN | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| P value | OR | 95%CI | P value | OR | 95%CI | P value | OR | 95%CI | ||||||
| rs9547952 | 37036688 | Exon 22 | C/T | 0.075 | 0.747 | >0.1 | 1.08 | 0.74–1.49 | >0.1 | 1.10 | 0.68–1.63 | >0.1 | 1.02 | 0.63–1.66 |
| rs9603226 | 37041585 | Intron 20 | G/A | 0.339 | 0.413 | >0.1 | 0.84 | 0.69–1.03 | >0.1 | 0.92 | 0.71–1.16 | 0.056 | 0.76 | 0.56–1.00 |
| rs7322993 | 37051129 | Intron 14 | C/T | 0.195 | 0.666 | 0.001* | 1.46 | 1.16–1.82 | 0.006* | 1.47 | 1.12–1.93 | 0.029 | 1.45 | 1.03–1.99 |
| rs7323378 | 37051350 | Intron 13 | T/C | 0.113 | 1.000 | >0.1 | 1.02 | 0.77–1.35 | >0.1 | 1.05 | 0.74–1.49 | >0.1 | 0.88 | 0.59–1.33 |
| rs9547965 | 37051887 | Intron 12 | G/A | 0.028 | 0.145 | >0.1 | 0.76 | 0.47–1.28 | >0.1 | 0.91 | 0.50–1.63 | 0.050 | 0.47 | 0.22–1.01 |
| rs17056105 | 37055419 | Intron 9 | A/T | 0.082 | 0.372 | >0.1 | 1.21 | 0.87–1.65 | >0.1 | 1.14 | 0.77–1.67 | >0.1 | 1.28 | 0.79–2.05 |
| rs12871092 | 37057632 | Intron 7 | A/G | 0.353 | 0.858 | >0.1 | 0.90 | 0.76–1.12 | >0.1 | 0.83 | 0.67–1.08 | >0.1 | 1.11 | 0.85–1.46 |
| rs7338244 | 37065052 | Intron 2 | C/G | 0.306 | 1.000 | 0.003* | 1.34 | 1.11–1.63 | 0.015 | 1.33 | 1.08–1.71 | >0.1 | 1.27 | 0.95–1.66 |
Two SNPs remained statistically significant after correction for multiple testing using FDR method. OR >1, the reference (minor) allele is associated with the higher risk of low BMD
B36 Genomic position, MAF minor allele frequency, HWE Hardy–Weinberg equilibrium, LS lumbar spine, FN femoral neck
*P FDR < 0.05