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. Author manuscript; available in PMC: 2012 Jun 6.
Published in final edited form as: Nature. 2011 Oct 19;479(7373):365–371. doi: 10.1038/nature10572

Fig. 4. The transgenerational inheritance of longevity by deficiencies in ASH-2 complex members is dependent on the presence of the H3K4me3 demethylase RBR-2 and of an intact germline.

Fig. 4

a–b, Lifespan of genetically wildtype F3 descendents from wdr-5(ok1417) mutant worms (+/+ from P0 wdr-5 parents) in the presence of empty vector (control RNAi) (a) or rbr-2 RNAi (b). c–d, Lifespan of pgl-1 F3 descendents from a wdr-5(ok1417);pgl-1(bn101) mutant worms (pgl-1/pgl-1 from P0 wdr-5;pgl-1 parents) compared to descendents from pgl-1(bn101) worms at the permissive temperature (16°C) (c) and at the restrictive temperature (25°C) (d). Mean lifespan and statistics are presented in Supplementary Tables 3 and 4.