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. 2012 Jun 6;102(11):2461–2470. doi: 10.1016/j.bpj.2012.04.015

Figure 1.

Figure 1

CaMKII increased twitch Δ[Ca]i transients but decreased diastolic [Ca]i in ventricular myocytes. (A) Representative steady-state twitch Δ[Ca]i during 1 Hz stimulation in KO and KO/TG myocytes using fura-2 as Ca indicator; (B) twitch Δ[Ca]i; (C) diastolic [Ca]i; (D) rise time (time to peak [Ca]i); (E) time constant τ of twitch [Ca]i decline using the indicated Ca sensors (n ≥ 10 cells in each group). ∗Significant difference between PLN-KO (KO) and CaMKIIδC-PLN-KO mice (KO/TG) at p < 0.05.