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Unaltered SR Ca load, but increased NCX function in KO/TG. (A) SR Ca content assessed by caffeine-induced Fluo-4 transient amplitude (Ca sensor is indicated in each subsequent panel); (B) SR Ca content; (C) time constant of [Ca]i decline during caffeine exposure (τNCX). (D) Fractional SR Ca release (twitch/caffeine-induced Δ[Ca]i). ∗Significant difference between KO and CaMKIIδC-PLN-KO mice at p < 0.05 (n ≥ 6 for all groups).
