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CaMKII inhibitor AIP reversed the increase of CaSpF and slowed twitch [Ca]i decline in KO/TG myocytes. (A) Time constant of twitch [Ca]i decline versus number of Ca sparks between twitch [Ca]i upstrokes; (B) computational model predictions of the impact of SR Ca leak on the τ of twitch [Ca]i decline (τtwitch); (C) CaMKII inhibitor AIP reversed higher resting CaSpF in KO/TG; (D) CaSpF between twitches; (E) delayed twitch [Ca]i relaxation in KO/TG.
