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(a) Scheme showing the reticulons distribution on endoplasmic reticulum and the physical connection between nuclear envelope and ER membrane. (b) Schematic diagram of RTN-1C and histone H4 proteins showing the shared GAKRH motif. The blue aminoacids indicate the two hydrophobic segments of RTN-1C protein. The red aminoacids indicate the three positive charges in the H4 consensus motif. RTN-1C is acetylated on Lys 204.
