Table 1.
Components of stress granules.
| Protein | Function | Interacting proteins |
|---|---|---|
| Ago2 | Cleaves interfered RNA | RISC, FXR1 |
| APOBEC3G | Antiviral response | ? |
| Ataxin-2 | Translation | PABP-1 |
| Caprin-1 | Cell growth | G3BP |
| CPEB | mRNA repression | RCK, eIF4E, FXR1 |
| DIS1 | Unknown | eIF3h |
| eIF3 | Translation | 40S, eIF4G |
| eIF4E | Translation | CPEB, Smaug, eIF4G, 4ET |
| eIF4G | Translation | eIF4E, eIF3, PABP-1 |
| FAST | Translation | TIA-1 |
| FMRP, FXR1 | Translation | Ago2, RISC |
| FBP, KSRP | mRNA degradation | TIA-1 |
| FUS/TLS | Transcriptional control | Transcriptional machinery |
| G3BP | Ras signalling | Caprin |
| HuR | mRNA stabilization | ? |
| IP5K | Signalling | ? |
| Lin28 | Developmental control | ? |
| LINE 1 ORF1p | Transposon | ? |
| MLN51 | Splicing | Exon junction |
| PABP-1 | Translation | eIF4G, eIF3, ataxina-2 |
| RCK(p54) | mRNA degradation | GE-1, TTP |
| Plakophilin | Adhesion | G3BP, FXR1 |
| PMR1 | mRNA degradation | TIA-1 |
| Pumilio 2 | mRNA silencing | ? |
| Rap 55 | mRNA silencing | ? |
| Rpb4 | Transcription | ? |
| SRC3 | Transcription | TIA-1 |
| Staufen | mRNA silencing | ? |
| SMN | RNP assembly | Complejo SMN |
| TDP-43 | Transcription and splicing regulator | eIF4G, eIF3, eIF2, ribosomal proteins, STAU-1, Xnr |
| TIA-1(rox-8), TIAR | mRNA silencing | FAST, SRC3, PMR1, FBP |
| TRAF2 | Signalling | eIF4G |
| TTP, BRF-1 | mRNA silencing | RCK (p54) |
| YB-1 | Cold shock | ? |
| ZBP1 | Localization | ? |