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. 2012 Jun 6;5:71. doi: 10.3389/fnmol.2012.00071

Figure 3.

Figure 3

Class 5 and class 6 transmembrane semaphorin signaling through plexinAs governs laminar targeting of inner retinal neuron subtypes. (A) Sema6A and PlexA4 show complementary protein expression in the ON and OFF layers of the inner plexiform layer, and this repulsive signaling confines neurite extension of dopaminergic amacrine cells (TH+) within the S1 sublamina in wild-type mice. In Sema6A or PlexA4 mutant mice, dopaminergic amacrine cells extend their aberrant processes to the S4/S5 sublaminae. (B) During early postnatal retinal development, Sema5A/5B and PlexA1/A3 expressions are found in a complementary pattern in the retina. Loss of Sema5A/5B or plexA1/A3 results in neurite mistargeting of multiple inner retinal neuron subtypes into the outer retina.