Table 1.
Selectivity over other ion channels.
| Channel | T122 (10 μM) | T136 (10 μM) |
|---|---|---|
| Kv1.1 | 65 ± 10% block (n = 5) | 28 ± 9% block (n = 5) |
| Kv1.3 | 52 ± 2% block (n = 3) | 18 ± 4% block (n = 3) |
| Kv2.1 | 28 ± 4% block (n = 3) | 28 ± 4% block (n = 3) |
| Kv3.1 | 32 ± 12% block (n = 5) | 37 ± 16% block (n = 4) |
| Kv4.2 | 16 ± 4% block (n = 3) | 15 ± 3% block (n = 3) |
| Kv7.2/7.3 | No effect (n = 3) | No effect (n = 2) |
| Kv11.1 (hERG) | 42 ± 3% block (n = 3) | 27 ± 4% block (n = 3) |
| KCa2.3 | No effect (n = 3) | No effect (n = 3) |
| KCa3.1 | IC50 = 10.2 ± 0.7 μM | IC50 = 1.3 ± 0.2 μM |
| KCa1.1 (BK) | 43 ± 4% (n = 3) | 26 ± 2% (n = 3) |
| Nav1.2 | 11 ± 1% block (n = 3) | 9 ± 0.5% block (n = 3) |
| Nav1.4 | No effect (n = 3) | No effect (n = 3) |
Percentage of current inhibition (mean ± SD) by 10 μM T122 and T136 for a panel of cloned Kv, KCa, or Nav channels. (For recording conditions and pulse protocols see Materials and Methods).