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. 2012 May 1;22(9):3349–3353. doi: 10.1016/j.bmcl.2012.02.107

Table 2.

SAR of disubstituted pyrimidines

Compound R1 or NHR1 PknB IC50/μMa M. tuberculosis MIC/μMa
8a graphic file with name fx16.gif 0.375 >500
8b graphic file with name fx17.gif 0.384 63
8c graphic file with name fx18.gif 0.393 31
8d graphic file with name fx19.gif 0.086 63
8e graphic file with name fx20.gif 0.241 63
8f graphic file with name fx21.gif 0.087 125
8g graphic file with name fx22.gif 0.202 125
8h graphic file with name fx23.gif 0.084 63
8i graphic file with name fx24.gif 0.354 63
8j graphic file with name fx25.gif 0.715 125
8k graphic file with name fx26.gif 0.074 63
8l graphic file with name fx27.gif 0.064 125
8m graphic file with name fx28.gif 0.217 250
8n graphic file with name fx29.gif 0.115 63
a

Assay conditions are described in Ref. 8.