Figure 3.

CTCF Motif Usage Shows a Conserved Hierarchy among Placental Mammals

Heat map of the 2,492 CTCF motif-words found at least five times in any species anchored to human; words are normalized by their background occurrences within each genome. This set of words is found in 27,543 human-binding events. The data are sorted in the human column by decreasing frequency, and spearman rank correlations after one-dimensional hierarchical clustering of the rows are shown. The average ChIP-enrichment of the motif-words separated into bins containing 100 words is shown as a bar chart (left). Similarly, the fraction of five-way conserved CTCF-binding events within the same bins are shown as a bar chart (right). See also Figure S3.