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SW620 cells were seeded at densities 250 × 103 cells/cm2 onto 1.5 and 4.0 mg/mL collagen I gels. ROCK-1 was knocked down via siRNA to study the impact of ROCK-I on cell invasion in a low- and high-density environment. ROCK-I knockdown resulted in a 60% increase in invasion for cells seeded in both 1.5 and 4.0 mg/mL scaffolds.
