Table 5.
Standardised effect sizes of between group differences in change adjusted for age, sex, centre and education
| Assessment | Premanifest HD versus controls |
Early HD versus controls |
||
| 12 months | 24 months | 12 months | 24 months | |
| SDMT (number correct) | ||||
| Effect size (95% CI) | 0.20 (−0.03 to 0.43) | 0.14 (−0.11 to 0.38) | 0.75 (0.51 to 1.06) | 1.00 (0.70 to 1.30) |
| Stroop Word Reading (number correct) | ||||
| Effect size (95% CI) | −0.01 (−0.22 to 0.24) | 0.15 (−0.11 to 0.43) | 0.50 (0.23 to 0.79) | 0.73 (0.48 to 1.03) |
| Trails A completion time (s) | ||||
| Effect size (95% CI) | 0.19 (−0.07 to 0.48) | −0.02 (−0.29 to 0.27) | 0.18 (−0.03 to 0.41) | 0.28 (0.10 to 0.44) |
| Trails B completion time (s) | ||||
| Effect size (95% CI) | −0.09 (−0.39 to 0.18) | 0.15 (−0.12 to 0.39) | −0.05 (−0.25 to 0.18) | 0.19 (0.00 to 0.39) |
| Paced Tapping 3 Hz precision (1/SD of ITI in 1/ms) | ||||
| Effect size (95% CI) | 0.11 (−0.20 to 0.42) | 0.19 (−0.14 to 0.53) | 0.48 (0.01 to 1.06) | 0.49 (0.07 to 1.01) |
| Paced Tapping 1.8 Hz precision (1/SD of ITI in 1/ms) | ||||
| Effect size (95% CI) | −0.07 (−0.32 to 0.17) | 0.11 (−0.20 to 0.40) | −0.04 (−0.34 to 0.25) | 0.32 (−0.02 to 0.74) |
| Serial 2 s with tapping (correct subtractions) | ||||
| Effect size (95% CI) | 0.07 (−0.15 to 0.32) | 0.14 (−0.13 to 0.42) | 0.33 (0.07 to 0.59) | 0.53 (0.24 to 0.81) |
| Spot the Change set size 5 (k) | ||||
| Effect size (95% CI) | −0.05 (−0.31 to 0.17) | 0.17 (−0.05 to 0.47) | 0.23 (−0.03 to 0.46) | 0.40 (0.16 to 0.68) |
| Negative Emotion Recognition (number correct) | ||||
| Effect size (95% CI) | −0.02 (−0.28 to 0.21) | 0.08 (−0.18 to 0.34) | 0.27 (0.03 to 0.52) | 0.49 (0.21 to 0.77) |
| UPSIT (number correct of 20) | ||||
| Effect size (95% CI) | −0.15 (−0.37 to 0.06) | −0.01 (−0.28 to 0.27) | 0.28 (0.08 to 0.48) | 0.38 (0.16 to 0.58) |
| Circle Tracing direct annulus length (log cm) | ||||
| Effect size (95% CI) | −0.01 (−0.25 to 0.26) | 0.10 (−0.15 to 0.34) | 0.15 (−0.12 to 0.40) | 0.58 (0.33 to 0.85) |
| Circle Tracing indirect annulus length (log cm) | ||||
| Effect size (95% CI) | 0.23 (−0.05 to 0.51) | 0.19 (−0.10 to 0.48) | 0.54 (0.30 to 0.79) | 0.85 (0.58 to 1.18) |
HD, Huntington's disease; ITI, inter-trial interval; SDMT, Symbol Digit Modalities Test; UPSIT, the University of Pennsylvania Smell Identification Test.