Figure 4.

Flow cytometric histograms of A549 spheroid cells incubated with composite doxorubicin-loaded micelles or free doxorubicin with the same doxorubicin densities for 2 hours and 3 hours. DOX for 2 hours, multicellular spheroids incubated in free doxorubicin for 2 hours; DOX for 3 hours, multicellular spheroids incubated in free doxorubicin for 3 hours; MIX for 2 hours, multicellular spheroids incubated in MIX for 2 hours; MIX for 3 hours, multicellular spheroids incubated in MIX for 3 hours.

Abbreviations: DOX, free doxorubicin; MIX, composite doxorubicin-loaded micelles.