Figure 8.

Spheroid proliferation following single mode and combinational treatment.

Notes: Each treatment group (sham, irradiation alone, blank composite micelle + irradiation, free doxorubicin + irradiation, composite doxorubicin-loaded micelle + irradiation) consists of 30 A549 spheroids in five independent experiments. Illustration of mean volume growth of spheroids following irradiation and irradiation alone + blank composite micelles, irradiation alone + doxorubicin, irradiation alone + MIX (composite doxorubicin-loaded micelles). A significant reduction in spheroid volume was observed following irradiation alone + MIX on day 9 (P < 0.05).

Abbreviations: DOX, free doxorubicin; MIX, composite doxorubicin-loaded micelles; RT, radiation alone.