Table 3.

Antimicrobial activity of ethanol leaf extract (CGLE) and ethanol stem bark extract (CGBE) of C. gigantea and ethanol leaf extract (PMLE) and ethanol stem bark extract (PMBE) of P. macrocarpa by agar diffusion method. Activity of the methanol (solvent) used to dissolve the extracts was determined. Mean zones of inhibition (plus diameter of well) are mean (mm) of 3 independent experiments, mean ± SD, n = 4 replicates, and diameter of well/cup = 10 mm. Reference antimicrobial agents: CPC: chloramphenicol (1 mg/mL); CTZ: clotrimazole (1 mg/mL); ND: Not determined.

	Mean zones of growth inhibition (mm)
Extract (mg/mL)	Test organisms
	S. aureus	B. subtilis	E. coli	P.  aeruginosa	C. albicans
	ATCC 25923	NCTC 10073	ATCC 25922	ATCC 27853
CGLE
10	19.67 ± 0.58	16.80 ± 0.40	12.20 ± 0.17	12.24 ± 0.13	12.65 ± 0.58
25	24.60 ± 0.53	19.33 ± 0.58	16.53 ± 0.24	15.50 ± 0.58	16.47 ± 0.48
50	28.33 ± 0.58	22.30 ± 0.42	19.67 ± 0.56	17.50 ± 0.47	22.13 ± 0.23
CGBE
10	16.67 ± 0.58	13.33 ± 0.58	12.30 ± 0.58	0.0	13.67 ± 0.58
25	13.00 ± 0.00	17.80 ± 0.35	14.12 ± 0.42	0.0	18.90 ± 0.48
50	18.67 ± 0.58	19.50 ± 0.50	18.67 ± 0.58	13.47 ± 0.58	21.85 ± 0.23
PMLE
10	0.0	17.80 ± 0.35	0.0	0.0	12.80 ± 0.20
25	14.60 ± 0.58	18.50 ± 0.50	19.33 ± 0.58	0.0	14.00 ± 0.00
50	19.67 ± 0.58	22.53 ± 0.12	21.47 ± 0.50	16.30 ± 0.23	22.33 ± 0.58
PMBE
10	0.0	12.33 ± 0.58	11.33 ± 0.58	0.0	12.80 ± 0.20
25	14.50 ± 0.50	14.67 ± 0.58	12.67 ± 0.58	0.0	15.40 ± 0.36
50	17.13 ± 0.23	16.73 ± 0.58	15.83 ± 0.29	12.3 ± 1.20	18.60 ± 0.58
CPC	25.67 ± 0.38	31.21 ± 0.38	30.67 ± 0.85	22.33 ± 0.38	ND
CTZ	ND	ND	ND	ND	25.60 ± 0.61
Methanol	0.0	0.0	0.0	0.0	0.0