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Schematic diagram of the PPARγ signaling. cPA is generated intracellularly in a stimulus-coupled manner by the PLD2 enzyme (1). cPA inhibits PPARγ activation and stabilizes binding of PPARγ corepressor SMRT (2). Agonists (LPA, alkyl-LPA, and rosiglitazone) activate PPARγ and promote downstream signals, whereas cPA negatively regulates PPARγ. cPA stabilizes PPARγ-SMRT corepressor complex and inhibits PPARγ-mediated postsignal transduction (3).
