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. Author manuscript; available in PMC: 2012 Jun 6.
Published in final edited form as: Biochem Soc Trans. 2008 Apr;36(Pt 2):149–155. doi: 10.1042/BST0360149

Figure 1. Protein-protein interactions between cadherins, catenins and the actin cytoskeleton.

Figure 1

Protein interactions formed between cadherin, β-catenin (β-cat), α-catenin monomers (α-catM), α-catenin dimers (α-catD) and actin. Differences in the thickness of the arrows represent strengths of protein-protein interactions (i.e. increased thickness shows increased binding). The interaction between cadherin and β-catenin is regulated by kinases that increase (green box: CK2 and GSK3β) or decrease (red box: Src, Fer, Abl and EGFR) the binding affinity.