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. Author manuscript; available in PMC: 2012 Jun 6.
Published in final edited form as: Annu Rev Biochem. 2007;76:267–294. doi: 10.1146/annurev.biochem.75.103004.142811

Figure 4.

Figure 4

Schematic representations of the immunologic synapse between T cells and antigen-presenting cells (APCs) (inset), adhesion proteins (boxed), and protein networks assembled at the synapse that remodel the T cell and initiate the immune response from the T cell. Abbreviations: ICAM-1, intercellular adhesion molecule 1; LAT, linker for activation of T cells; LFA-1, lymphocyte function-associated antigen 1; MHC, major histocompatibility complex; Par3, partition defective 3; PLCγ, phospholipase C γ; SLP-76, Src homology 2 domain-containing leukocyte-specific phosphoprotein of 76 kDa; TCR, T-cell receptor; WASP, Wiskott-Aldrich syndrome protein; WIP, WASP-interacting protein; ZAP70, zeta-chain-associated protein 70.