Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Reagents and conditions: (a) (1) propylamine, NaBH(OAc)3, THF, HOAc, RT, 1 h, reflux 18 h; (2) HCl in Et2O, Et2O; (b) 4-bromobutyronitrile, K2CO3, KI, CH3CN, reflux, 24 h; (c) LiAlH4 in Et2O, Et2O, RT, 1 h; (d) 4-biphenylcarboxylic acid chloride, Et3N, CH2Cl2, RT, 21 h; (e) ferrocene carboxylic acid, HATU, DIPEA, DMF, RT, 3 h; (f) [2.2]paracyclophane carboxylic acid, HATU, DIPEA, CH2Cl2, NMP, RT, 2.75−3 h; (g) propionaldehyde, NaBH(OAc)3, THF, HOAc, reflux 21 h.
