Table 2. Functional Activity of Representative mGluR2 PAMs 5, 41−68^a.

compound	R2	mGlu2 EC50 (μM)a	mGlu2 Emax (%)
5	Ph-	6.29	138
41	2-F-Ph-	1.00	44
42	3-F-Ph-	1.91	96
43	4-Cl-Ph-	1.41	189
44	4-OH-Ph-	>10
45	4-CF3O-Ph-	0.24	228
46	2,3-diF-Ph-	10	131
47	2,4-diF-Ph-	4.79	128
48	2,4,6-triF-Ph-	2.96	118
49	3-F-4-Cl-Ph-	0.48	180
50	2-F-4-CF3−Ph-	3.16	124
51	3-Py-	>10
52	3-(6-MeO)Py-	6.03	66
53	3-(6-CF3)Py-	6.76	144
54	4-(2-Me)-triazolyl-	>10
55	2-benzimidazolyl-	>10
56	2-benzothiazolyl-	5.62	79
57	PhCH2CH2-	3.71	117
58	PhOCH2-	3.98	87
59	3-Cl-PhOCH2-	3.16	124
60	4-Cl-PhOCH2-	1.91	115
61	n-propyl-	7.24	53
62	n-butyl-	9.28	122
63	i-butyl-	0.54	75
64	s-butyl-	12.88	97
65	CF3CH2CH2-	8.71	97
66	cyclopentyl-	9.33	122
67	cyclohexyl-	0.43	120
68	cyclohexylmethyl-	1.08	161

^aValues are means of three experiments.