Table 3. Metabolic Stability in Human Liver Microsomes (HLM) of Some Representative Compounds.
compound | HLMa (%) |
---|---|
7 | 70 |
8 | 100 |
12 | 24 |
13 | 35 |
15 | 64 |
16 | 83 |
18 | 82 |
20 | 100 |
22 | 87 |
30 | 59 |
31 | 73 |
45 | 98 |
HLM data refer to the percentage of compound metabolized after 15 min at 5 μM concentration.