Figure 3.

Negative Controls. (A) Four drugs that act on the nervous system but do not have antipsychotic properties including propanolol, fluoxetine, lamotrigine, and chlorpheniramine (chlorphenir) failed to suppress DAF-16::GFP nuclear localization. (B) Clozapine, olanzapine, and trifluoperazine do not affect general nuclear transport. Nuclear localization of proteins known to shuttle in and out of the nucleus was measured in response to treatment with clozapine, olanzapine, and trifluoperazine. GFP-tagged proteins tested include the transcription factors MEC-3 and PAG-3 and a β-tubulin, MEC-7, with an added nuclear localization sequence.