Table 1. Antipsychotic Drugs Stimulate Recovery from Dauera.
| concentration (μM) |
|||||||
|---|---|---|---|---|---|---|---|
| drug | 160 | 80 | 40 | 20 | 10 | 5 | 2.5 |
| chlorprothixene | − | R | R | R | R | R | R |
| clozapine | R | R | R | R | R | (±) | − |
| haloperidol | R | (±) | D | D | D | D | − |
| olanzapine | R | R | R | (±) | D | D | − |
| quetiapine | R | R | (±) | D | D | D | − |
| trifluoperazine | − | R | R | R | (±) | D | D |
| xanomeline | − | (±) | D | D | D | D | D |
| DMSO | D | D | D | D | D | D | − |
| % | |||||||
| 1 | 0.25 | 0.0625 | 0.0156 | 0.00391 | 0.0009 | − | |
| yeast extract | R | R | R | (±) | D | D | − |
a
Antipsychotic drugs stimulate recovery from dauer. Yeast extract served as a positive control. DMSO was used as the solvent for each of the drugs; therefore, DMSO alone at the concentrations used in each well was tested as a negative control. Haloperidol formed crystals at 160 μM so that concentration is not accurate. When this experiment was repeated with the daf-2(e1370) mutant, no animals recovered from the dauer state.