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. 2010 Oct 7;1(12):796–809. doi: 10.1021/cn100073x

Figure 4.

Figure 4

Voltage-dependence of bicyclic alcohol 5 inhibition at α4β2 wildtype nAChRs. (A) Current−voltage curves obtained by clamping cells (n = 4) between −90 mV and 0 mV in 10 mV steps, with ACh (100 μM) alone (◻) or ACh (100 μM) in the presence of bicyclic alcohol (30 μM) (●). Data is normalized to current generated by ACh (100 μM) alone held at −90 mV. (B) Plot of ACh (100 μM) current block expressed as the ratio of blocked current (30 μM bicyclic alcohol 5) over ACh control current (IDrug/IACh) versus membrane potentials (n = 4). Bicyclic alcohol 5 (30 μM) exerts a stronger block at more negative potentials.