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Typical transaxial positron emission tomography (PET) images showing [11C]MBF (A, C) and [11C]JP-1302 (B, D) in the brain of a wild-type mouse (A, B) and a P-gp/Bcrp knockout mouse (C, D). Injected dose was 3.7−4.7 MBq/0.071−0.56 nmol. PET images were acquired from 5 to 60 min after the injection. Mice were anesthetized with isoflurane and fixed in a prone position on the bed of the scanner.
