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Fluorescent staining of chalcone derivatives 9 (A), 12 (C), 15 (E), and 18 (G) in 10-μm Tg2576 mouse brain sections. Labeled plaques were confirmed by staining of the adjacent sections with thioflavin-S (B, D, F, H). No apparent staining of 18 (I) was observed in the age-matched control mouse brain section.
