Table 2.
Functional classification of genes consist of HDNs for IBD
| HDN | Functional category | Gene |
|---|---|---|
| IBDmild | immunoregulation |
ICAM1, IL2, IL23A, IL23R, IL4, CRP, IL11, IL2RA, IL4R, IRAK3, TYK2 |
| innate immunity | CD14, TLR2, TLR4, TLR1, TLR6, IFNG, IL8 | |
| inflammation and immunoregulation |
CCL2, IL12B, IL17, IL1A, IL1RN, NFKB1, NFKBIA, CCL11, CCL26, IL10RA, IL18RAP |
|
| inflammation and apoptosis | IL1B, IRF5, TNFSF1A, IL15, JAK2, STAT6 | |
| cell growth, apoptosis and tumorigenesis | TP53, PTPN11, STAT3, TGFB1 | |
| atherosclerosis and tissue remodeling | SERPINE1, TIMP1, A2M | |
| diabetes related | PPARG | |
| prostaglandin biosynthesis | PTGS1, PTGS2 | |
| IBDsevere | immunoregulation |
ICAM1, IL2, IL23A, IL23R, IL4, B2M, CD28, CX3CL1, CTLA4, HLA-C, KLRC1, IL12A, IL12RB2, STAT2, STAT4 |
| innate immunity | CD14, TLR2, TLR4, IFNG, IL8 | |
| inflammation and immunoregulation |
CCL2, IL12B, IL17, IL1A, IL1RN, NFKB1, NFKBIA, CCL5, CSF2, IL1R1, IL6, IL6R, IL18, NR3C1 |
|
| inflammation and apoptosis | IL1B, IRF5, TNFSF1A, IL15 | |
| apoptosis | FASLG, TNFAIP3, TNFRSF1B, TRADD | |
| cell growth and tumorigenesis | TP53, IGF1, IGFBP3, TGFB1, TGFBR1, SOCS1 | |
| aging and tumorigenesis | SOD1, SOD2 | |
| atherosclerosis and tissue remodeling | SERPINE1, TIMP1, EDN1, MMP3, PLAT, SELE | |
| diabetes related | PPARG, LEP, PPARA | |
We annotated the genes by their functions according to EntrezGene database.