Table 1.
Intracellular signal mediators showing aberrant expression in SSc
| Molecule | Increased expression/activity | Decreased expression/activity |
|---|---|---|
| Egr-1, Egr-2 | ⇑ | |
| Sp1 | ⇑ | |
| p300/CBP | ⇑ | |
| Fli-1 | ⇓ | |
| Smad7 | ⇓ | |
| Ski/Sno | ⇓ | |
| Nab2 | ⇓ | |
| PTEN | ⇓ | |
| PPAR-gamma | ⇓ | |
| microRNA29 | ⇓ |
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