Table 2.
Functionally connected clusters as indicated by a seed region of interest (ROI) prescribed in the posterior cingulate cortex and covarying for the effects of total gray matter volume for non-cognitively impaired participants (NCI) and mild cognitive impaired participants (MCI)
| Group | Region | Cluster Size (# voxels) | Maximum Intensity Voxel coordinates | t-value | ||
|---|---|---|---|---|---|---|
| NCI | ||||||
| Widespread bilateral posterior cingulate, medial and lateral parietal, temporal, occipital, basal ganglia, thalamus | 5393 | 0 | −54 | 27 | 51.6306 | |
| Widespread bilateral medial frontal, anterior cingulate | 2573 | −3 | 63 | 0 | 9.0885 | |
| L middle temporal | 160 | −63 | −15 | −18 | 7.2618 | |
| R middle temporal | 95 | 63 | −9 | −21 | 6.7549 | |
| R cerebellum | 90 | 6 | −54 | −42 | 6.0595 | |
| L superior temporal | 5 | −39 | 21 | −30 | 4.9723 | |
| L cerebellum | 74 | −30 | −78 | −39 | 4.6772 | |
| R orbital frontal | 6 | 45 | 30 | −12 | 4.5782 | |
| R cerebellum | 61 | 33 | −75 | −39 | 4.5446 | |
| L middle temporal | 5 | −48 | 6 | −36 | 4.2848 | |
| R insula | 5 | 36 | −12 | 21 | 4.2836 | |
| L thalamus | 26 | −9 | −21 | 6 | 4.2180 | |
| L brainstem | 8 | 0 | −33 | −6 | 4.1424 | |
| R cuneus | 9 | 9 | −93 | 21 | 4.0907 | |
| R caudate | 8 | 18 | 21 | −6 | 3.9912 | |
| R thalamus | 12 | 6 | −18 | 3 | 3.9550 | |
| R inferior frontal | 11 | 57 | 24 | 3 | 3.8836 | |
| R inferior frontal | 5 | 36 | 24 | 24 | 3.7365 | |
| L inferior frontal | 10 | −51 | 24 | 6 | 3.6707 | |
| L orbital frontal | 6 | −48 | 33 | −12 | 3.5388 | |
| MCI | ||||||
| Widespread bilateral posterior cingulate, medial and lateral parietal, temporal, occipital, basal ganglia, thalamus | 4131 | 0 | −54 | 27 | 53.8787 | |
| Widespread bilateral medial frontal, anterior cingulate | 2426 | 3 | 54 | 12 | 10.1883 | |
| L middle temporal | 216 | −66 | −12 | −18 | 7.9563 | |
| R middle temporal | 142 | 63 | −3 | −24 | 7.4053 | |
| R cerebellum | 41 | 9 | −54 | −45 | 6.5141 | |
| L cerebellum | 29 | −9 | −57 | −45 | 6.4655 | |
| L cerebellum | 48 | −30 | −81 | −33 | 5.1676 | |
| R parahippocampal | 5 | 27 | −33 | −18 | 4.6878 | |
| R cerebellum | 36 | 42 | −69 | −39 | 4.5733 | |
| R superior temporal | 17 | 45 | 21 | −33 | 4.5437 | |
| R cerebellum | 74 | 30 | −84 | −30 | 4.3973 | |
| R thalamus | 5 | 9 | −12 | 9 | 4.3221 | |
| L cerebellum | 15 | −42 | −63 | −48 | 4.2190 | |
| L brainstem | 9 | −3 | −30 | −6 | 4.1668 | |
| L caudate | 8 | −15 | 18 | −3 | 4.1087 | |
| R middle temporal | 20 | 63 | −33 | −9 | 3.9644 | |
| R anterior cingulate | 9 | 3 | 18 | 18 | 3.8263 | |
| R middle temporal | 9 | 63 | −24 | −18 | 3.7045 | |
Seed ROI MNI coordinates: x = 0, y = −53, z = 26; radius = 4mm; p < 0.001, cluster size >5 voxels, false-discovery rate (FDR) corrected at p < .01.