Figure 4. Comparative efficacy study of vaccine candidates in S. aureus bacteremia and pneumonia infection models.

Survival of mice vaccinated with the three vaccine candidates and control mice after IP challenge with 5×10⁴ CFU of USA300 along with Hog Mucin (A) or IN challenge with 6×10⁷ CFU of S. aureus strain Newman (B). Survival of mice vaccinated with AT-62aa and challenged IN with 1.5×10⁸ CFU of S. aureus USA300 (C). Symbol key: AT-50aa (open circle), AT-62aa (black square), AT-79aa (open triangles) and mock-immunized mice (grey diamond). Statistical analysis was performed using Log-Rank (Mantel-Cox) test.