Table 1. Logistic regression analysis for the association between plasma 25-0HD on colorectal cancer risk.
| N | Crude model | Model I* | Model II† | ||||||||
| Standard logistic regression analysis | Cases | Controls | OR | 95% CI | p-value | OR | 95% CI | p-value | OR | 95% CI | p-value |
| 25-OHD (continuous; ng/ml) | 2001 | 2237 | 0.76 | 0.71, 0.81 | 1.4×10−14 | 0.75 | 0.70, 0.81 | 9.13×10−15 | 0.75 | 0.69, 0.81 | 4.6×10−12 |
| 25-0HD (binary) | |||||||||||
| <10 ng/ml | 973 | 826 | 1.00 | 1.00 | 1.00 | ||||||
| ≥10 ng/ml | 1028 | 1411 | 0.62 | 0.55, 0.70 | 1.2×10−14 | 0.61 | 0.54, 0.69 | 7.1×10−15 | 0.62 | 0.54, 0.72 | 6.1×10−11 |
| 25-0HD (quintiles) | |||||||||||
| <5.31 | 486 | 366 | 1.00 | 1.00 | 1.00 | ||||||
| 5.31–9.39 | 461 | 425 | 0.82 | 0.68, 0.99 | 0.04 | 0.82 | 0.68, 0.99 | 0.04 | 0.75 | 0.61, 0.94 | 0.01 |
| 9.39–13.20 | 376 | 430 | 0.66 | 0.54, 0.80 | <0.0005 | 0.66 | 0.54, 0.80 | <0.0005 | 0.67 | 0.53, 0.83 | <0.0005 |
| 13.20–18.36 | 358 | 505 | 0.53 | 0.44, 0.65 | <0.0005 | 0.53 | 0.44, 0.64 | <0.0005 | 0.49 | 0.39, 0.61 | <0.0005 |
| ≥18.36 | 320 | 511 | 0.47 | 0.39, 0.57 | <0.0005 | 0.46 | 0.38, 0.56 | <0.0005 | 0.45 | 0.35, 0.56 | <0.0005 |
| p-value trend | 2.2×10−18 | 7.8×10−19 | 3.6×10−15 | ||||||||
*
Adjusted for age and sex.
†
Adjusted for age, sex, Carstairs Deprivation Index, energy (MJoules/ day), smoking (non-smoker, former smoker and current smoker), body mass index (BMI, kg/m2, continuous), regular Non Steroidal Anti-Inflammatory Drug (NSAID) intake (yes vs. no), family history of cancer and physical activity (hours of cycling and other sports activities, 4 groups).