Table 3. Association between colorectal cancer risk and rs2282679, rs12785878, rs10741657 and rs6013897.
| Standard logistic regression analysis* | Case/control status | Mean (SD) of25-0HD (ng/ml) | Crude model | Model I† | ||||||
| All-samples | Cases | Controls | Cases | Controls | OR | 95% CI | p-value | OR | 95% CI | p-value |
| rs2282679 | ||||||||||
| CC | 216 | 218 | 11.63 (7.45) | 12.59 (8.45) | 1.00 | 1.00 | ||||
| AC | 1130 | 1160 | 11.01 (7.82) | 13.29 (8.24) | 0.98 | 0.80, 1.21 | 0.87 | 0.99 | 0.81, 1.21 | 0.92 |
| AA | 1325 | 1400 | 12.00 (7.86) | 14.01 (8.65) | 0.96 | 0.78, 1.17 | 0.66 | 0.96 | 0.78, 1.17 | 0.68 |
| per A allele | 0.97 | 0.90, 1.06 | 0.55 | 0.97 | 0.90, 1.06 | 0.55 | ||||
| rs12785878 | ||||||||||
| GG | 81 | 112 | 9.16 (7.29) | 10.67 (7.11) | 1.00 | 1.00 | ||||
| TG | 749 | 798 | 10.89 (7.50) | 13.50 (8.20) | 1.30 | 0.96, 1.76 | 0.09 | 1.30 | 0.96, 1.76 | 0.09 |
| TT | 1667 | 1713 | 11.69 (7.72) | 13.59 (8.59) | 1.35 | 1.00, 1.80 | 0.05 | 1.35 | 1.00, 1.81 | 0.05 |
| per T allele | 1.08 | 0.98, 1.20 | 0.11 | 1.08 | 0.98, 1.20 | 0.11 | ||||
| rs10741657 | ||||||||||
| GG | 851 | 855 | 11.15 (7.58) | 13.82 (8.88) | 1.00 | 1.00 | ||||
| GA | 1082 | 1201 | 11.54 (7.88) | 13.19 (8.25) | 0.91 | 0.80, 1.03 | 0.12 | 0.90 | 0.79, 1.02 | 0.11 |
| AA | 402 | 371 | 11.82 (7.62) | 13.78 (8.51) | 1.09 | 0.92, 1.29 | 0.33 | 1.08 | 0.91, 1.29 | 0.35 |
| per A allele | 1.01 | 0.94, 1.10 | 0.72 | 1.01 | 0.93, 1.10 | 0.77 | ||||
| rs6013897 | ||||||||||
| AA | 92 | 83 | 12.44 (8.83) | 13.89 (11.98) | 1.00 | 1.00 | ||||
| TA | 739 | 806 | 11.45 (7.29) | 12.84 (8.44) | 0.83 | 0.60, 1.13 | 0.24 | 0.84 | 0.61, 1.15 | 0.27 |
| TT | 1615 | 1648 | 11.32 (7.83) | 13.72 (8.34) | 0.88 | 0.65, 1.20 | 0.43 | 0.90 | 0.66, 1.21 | 0.48 |
| per T allele | 1.02 | 0.92, 1.13 | 0.71 | 1.02 | 0.92, 1.13 | 0.68 | ||||
| Allele score | 2815 | 2924 | 1.00 | 0.97, 1.04 | 0.87 | 1.01 | 0.97, 1.04 | 0.69 | ||
| “Synthesis” allele score | 2630 | 2761 | 1.04 | 0.98, 1.10 | 0.17 | 1.04 | 0.99, 1.10 | 0.14 | ||
| “Metabolism” allele score | 2779 | 2884 | 0.99 | 0.94, 1.05 | 0.79 | 0.99 | 0.94, 1.05 | 0.82 | ||
| <10ng/ml 25-0HD levels | Cases | Controls | OR | 95% CI | p-value | OR | 95% CI | p-value | ||
| rs2282679 | ||||||||||
| CC | 66 | 67 | 6.01 (2.84) | 5.71 (3.05) | 1.00 | 1.00 | ||||
| AC | 392 | 306 | 5.21 (2.90) | 5.54 (2.97) | 1.30 | 0.90, 1.89 | 0.17 | 1.29 | 0.89, 1.88 | 0.17 |
| AA | 399 | 368 | 5.47 (2.78) | 5.81 (2.79) | 1.10 | 0.76, 1.59 | 0.61 | 1.10 | 0.76, 1.59 | 0.61 |
| per A allele | 0.96 | 0.82, 1.12 | 0.58 | 0.96 | 0.82, 1.12 | 0.60 | ||||
| rs12785878 | ||||||||||
| GG | 32 | 40 | 3.98 (2.79) | 5.18 (3.12) | 1.00 | 1.00 | ||||
| TG | 249 | 221 | 5.37 (2.87) | 5.88 (2.81) | 1.41 | 0.86, 2.32 | 0.18 | 1.41 | 0.86, 2.32 | 1.18 |
| TT | 526 | 454 | 5.52 (2.83) | 5.66 (2.90) | 1.45 | 0.89, 2.34 | 0.13 | 1.46 | 0.90, 2.36 | 0.13 |
| per T allele | 1.10 | 0.93, 1.31 | 0.27 | 1.11 | 0.93, 1.32 | 0.25 | ||||
| rs10741657 | ||||||||||
| GG | 296 | 216 | 5.55 (2.84) | 5.60 (2.99) | 1.00 | 1.00 | ||||
| GA | 346 | 339 | 5.45 (2.81) | 5.74 (2.85) | 0.74 | 0.59, 0.94 | 0.01 | 0.74 | 0.59, 0.94 | 0.01 |
| AA | 113 | 98 | 5.11 (2.73) | 5.61 (2.79) | 0.84 | 0.61, 1.16 | 0.29 | 0.84 | 0.61, 1.17 | 0.31 |
| per A allele | 0.88 | 0.75, 1.02 | 0.09 | 0.88 | 0.75, 1.02 | 0.10 | ||||
| rs6013897 | ||||||||||
| AA | 23 | 24 | 5.00 (2.62) | 4.55 (2.71) | 1.00 | 1.00 | ||||
| TA | 237 | 233 | 5.66 (2.74) | 5.36 (3.06) | 1.06 | 0.58, 1.93 | 0.85 | 1.07 | 0.59, 1.96 | 0.82 |
| TT | 531 | 437 | 5.35 (2.84) | 5.88 (2.78) | 1.27 | 0.71, 2.28 | 0.43 | 1.29 | 0.72, 2.31 | 0.40 |
| per T allele | 1.17 | 0.97, 1.41 | 0.10 | 1.18 | 0.98, 1.42 | 0.09 | ||||
| ≥10 ng/ml 25-0HD levels | Cases | Controls | OR | 95% CI | p-value | OR | 95% CI | p-value | ||
| rs2282679 | ||||||||||
| CC | 69 | 96 | 17.01 (6.46) | 17.34 (7.68) | 1.00 | 1.00 | ||||
| AC | 380 | 525 | 17.00 (6.71) | 17.80 (6.86) | 1.01 | 0.72, 1.41 | 0.97 | 1.01 | 0.72, 1.42 | 0.94 |
| AA | 487 | 676 | 17.35 (6.53) | 18.48 (7.40) | 1.00 | 0.72, 1.39 | 0.99 | 1.00 | 0.72, 1.39 | 0.99 |
| per A allele | 1.00 | 0.87, 1.14 | 0.98 | 0.99 | 0.87, 1.14 | 0.93 | ||||
| rs12785878 | ||||||||||
| GG | 23 | 43 | 16.36 (5.11) | 15.78 (5.86) | 1.00 | 1.00 | ||||
| TG | 246 | 374 | 16.47 (6.55) | 18.00 (6.91) | 1.23 | 0.72, 2.09 | 0.45 | 1.24 | 0.73, 2.11 | 0.43 |
| TT | 584 | 782 | 17.24 (6.41) | 18.21 (7.34) | 1.40 | 0.83, 2.34 | 0.21 | 1.40 | 0.83, 2.35 | 0.20 |
| per T allele | 1.15 | 0.98, 1.35 | 0.09 | 1.15 | 0.98, 1.35 | 0.09 | ||||
| rs10741657 | ||||||||||
| GG | 271 | 401 | 17.27 (6.30) | 18.26 (7.78) | 1.00 | 1.00 | ||||
| GA | 383 | 542 | 17.04 (6.87) | 17.85 (7.00) | 1.05 | 0.85, 1.28 | 0.67 | 1.04 | 0.85, 1.27 | 0.70 |
| AA | 148 | 170 | 16.94 (5.99) | 18.50 (6.98) | 1.29 | 0.98, 1.69 | 0.07 | 1.28 | 0.98, 1.68 | 0.07 |
| per A allele | 1.12 | 0.98, 1.27 | 0.09 | 1.11 | 0.98, 1.27 | 0.10 | ||||
| rs6013897 | ||||||||||
| AA | 35 | 37 | 17.33 (8.01) | 19.95 (11.77) | 1.00 | 1.00 | ||||
| TA | 249 | 350 | 16.96 (5.86) | 17.82 (7.09) | 0.75 | 0.46, 1.23 | 0.25 | 0.76 | 0.47, 1.24 | 0.28 |
| TT | 545 | 774 | 17.13 (6.69) | 18.15 (7.07) | 0.74 | 0.46, 1.20 | 0.22 | 0.75 | 0.47, 1.21 | 0.24 |
| per T allele | 0.94 | 0.80, 1.10 | 0.44 | 0.94 | 0.80, 1.10 | 0.44 | ||||