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. 2012 Jun 6;7(6):e38087. doi: 10.1371/journal.pone.0038087

Figure 3. Estimates of rdnsv over different allele frequency bins.

Figure 3

The estimates of rdnsv decrease with SNV allele frequency in all gene categories. The slope of the fitted regression model can be interpreted as a measure for the influence of purifying selection on segregating nsSNVs. The y-intercept (rdnsv0) can be interpreted as the proportion of nsSites where mutations are tolerated to segregate with an allele frequency notably greater than 0. A) Expression-based NSGs (circles), ISGs (triangles) or RSGs (crosses). The fitted models are rdnsv(NSG) = 0.45−0.061×; rdnsv(ISG) = 0.58−0.079× and rdnsv(RSG) = 0.58−0.071×B) Keyword based NSGs (blue) and ISGs (red). The fitted models are rdnsv(NSG) = 0.43−0.061×; rdnsv(ISG) = 0.58−0.045×.