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. Author manuscript; available in PMC: 2013 Jul 10.
Published in final edited form as: Oncogene. 2012 Feb 27;32(2):141–150. doi: 10.1038/onc.2012.41

Figure-4. α9β1 induces cellular changes of EMT and enhanced cancer cell migration and invasion.

Figure-4

A, Flow cytometry analysis showing the extent of α9β1 surface expression (shaded histograms) on cells as indicated; and isotype antibody control (clear histogram). B, Immunoblots for α9, β1, E-cadherin or N-cadherin in lysates from mouse (LLC-1) or human NSCLC and SCLC cell lines. C, Cell adhesion on plastic (no matrix) or TnfnRAA with (black) or without (grey) α9β1 inhibitor, VLO5. D, Cell migration in the presence (black) or absence (grey) of TnfnRAA and/or VLO5. E, Cell invasion using cells stimulated by TnfnRAA and treated with (black) or without (grey) VLO5. F, Immunoblots to detect the EMT markers E-cadherin and vimentin in lysates from cells grown on plastic (no matrix) or TnfnRAA or with TGF-β.