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In Situ Hybridization for high risk HPV and p16INK4a immunohistochemistry staining of the patient’s tumor tissue. A, In situ hybridization (blue stain) demonstrating rare punctate signals (arrows) within the nucleus indicative of integrated HPV DNA. B, p16INK4a immunohistochemistry demonstrating dark nuclear and diffuse cytoplasmic staining on an adjacent tumor tissue section to that used for in situ hybridization.
