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. Author manuscript; available in PMC: 2013 Jun 1.
Published in final edited form as: J Cardiovasc Pharmacol. 2012 Jun;59(6):529–538. doi: 10.1097/FJC.0b013e31824dd15b

Figure 9. Putative scheme for the influence of high salt on nNOS and oxidative stress within the renal cortex of the mRen2.Lewis rat.

Figure 9

High salt may induce oxidative stress in the renal cortex by increasing nNOS expression but reducing the cofactor BH4 which may uncouple nNOS and increase superoxide production (O2-). High salt also reduces eNOS expression which may contribute to lower levels of nitric oxide (NO) and salt-dependent hypertension. The nNOS inhibitor L-VNIO may attenuate the nNOS-dependent formation of O2- to reduce renal fibrosis, inflammation, albuminuria, and renal hypertrophy without altering blood pressure.